Correct answer: Color is mapped to taxonomic family, size is mapped to prevalence, the diseases are represented using the point geometry.
What does the data frame look like that made this plot? (taxonomy is a categorical variable with three categories: bacteria, virus, and protoza, prevalence is proportion of population affected by disease, seems that disease is the observation so each point is a disease.)
What determines where the bubbles are placed in the chart? Answer: bubble charts have different methods of doing this. This one appears to use a packing algorithm so get them close together. Important, none of those methods refer to a column in the data frame therefore are not aesthetic mappings.
nice example of bubble chart that might appeal at https://www.mekkographics.com/top-english-premier-league-goal-scorers/
If you really want to go far afield, you could show an example of a beeswarm chart, which is a bubble chart that uses one of the x or the y to map a numerical variable and then uses a packing algorithm to determine placement on the other axis. Here is one showing [Sherlock Holmes canon and adaptations]https://public.tableau.com/app/profile/jessica.bautista/viz/SherlockHolmesCanon/Beeswarm
One of the lessons of this bubble chart is that our “named” charts correspond to particular combos of aesthetic mappings and geometriess. A “scatterplot” uses the point geometry and maps numerical data to the x and y axes. A “bubble chart” uses the point geometry too, but maps size to a numerical variable (and often uses color too), so adds two more variables.